Study of the thermodynamics and conformational changes of collagen molecules upon self-assembly

The emphasis on mechanism of collagen self-assembly shows great significance for development of collagen-based materials with targeted attributes. Here, combination of isothermal titration calorimetry (ITC) dilution experiments, circular dichroism (CD) and FTIR measurements were employed to investigate the thermodynamic differences and corresponding mechanisms associated with self-assembly of acid-soluble collagen (ASC) and pepsin-soluble...