Tweak to Treat: Reprograming Bacteria for Cancer Treatment

Certain groups of bacteria, such as tumor-targeting bacteria and probiotics, have innate antitumor properties that can be harnessed to suppress and regress cancers. These bacteria can be manipulated to deliver therapeutic payloads into the TME at effective dosages.Advancements in synthetic biology have enabled the screening, characterization, and modification of genetic tools that can exert control over the bacterial expression of therapeutic...