Palmitoyl piperidinopiperidine, a novel derivative of 10‑hydroxy‑2‑decenoic acid, as a potent and selective anticancer agent against human colon carcinoma cell lines

The present study, to the best of our knowledge, is the first systematic study of the inhibitory effects of palmitoyl piperidinopiperidine (PPI; Japan Patent no. 5597427), on colon carcinogenesis. PPI exhibited marked growth inhibitory activity in several human colon carcinoma cell lines, with IC50 values of approximately 0.5‑2.2 µM. In silico docking analysis indicated that PPI could bind to the SH2 domain of signal transducer and activator of...