Tazemetostat for advanced epithelioid sarcoma: current status and future perspectives
Abstract
Epithelioid sarcoma (ES) is an aggressive ultra-rare soft-tissue sarcoma marked by SMARCB1/INI1 deficiency. SMARCB1/INI1 deficiency leads to elevated expression of EZH2, a component of polycomb repressive complex 2, which mediates gene silencing by catalyzing H3K27me3. Tazemetostat is an oral, SAM-competitive inhibitor of EZH2, whose blockade prevents the methylation of histone H3K27, thus decreasing the growth of EZH2 mutated or over-expressing...
Paper Details
Title
Tazemetostat for advanced epithelioid sarcoma: current status and future perspectives
Published Date
Apr 1, 2021
Journal
Volume
17
Issue
10
Pages
1253 - 1263
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