Structural insights into TSC complex assembly and GAP activity on Rheb
Abstract
Tuberous sclerosis complex (TSC) integrates upstream stimuli and regulates cell growth by controlling the activity of mTORC1. TSC complex functions as a GTPase-activating protein (GAP) towards small GTPase Rheb and inhibits Rheb-mediated activation of mTORC1. Mutations in TSC genes cause tuberous sclerosis. In this study, the near-atomic resolution structure of human TSC complex reveals an arch-shaped architecture, with a 2:2:1 stoichiometry of...
Paper Details
Title
Structural insights into TSC complex assembly and GAP activity on Rheb
Published Date
Jan 12, 2021
Journal
Volume
12
Issue
1
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