Potential Functional Restoration of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy by ROCK Inhibitor (Ripasudil)

•Ripasudil stimulates cell cycle progression and cell migration of central corneal endothelial cells of FECD patients in situ. •Ripasudil upregulates key proteins of endothelial pump and barrier function in situ. •Ripasudil supresses endothelial-to-mesenchymal transition in situ. •Ripasudil was effective in the presence of pathological guttae. Purpose Rho-associated kinase (ROCK) inhibitors have been successfully used as a rescue strategy in...