550 Novel 3D model systems to assess heterogeneity in response to platinum therapy in high grade serous ovarian cancer

Introduction/Background

High-grade serous ovarian cancer (HGSOC) is the most common subtype of ovarian cancer, characterised by vast genomic instability and heterogeneity and acquired resistance to platinum-based chemotherapy. However, matching the most beneficial treatment options to patients is difficult to predict due to different platinum resistance mechanisms and limited effective predictive biomarkers. A study characterising...