Original paper
Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research
Abstract
Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority of promising preclinical drugs have no or weak efficacy in real patients with tumors, thereby delaying the discovery of successful therapeutics. This is because 2D culture lacks cell–cell contacts and natural tumor microenvironment, important in tumor signaling...
Paper Details
Title
Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research
Published Date
Dec 6, 2020
Journal
Volume
12
Issue
12
Pages
1186 - 1186
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Notes
History