LDpred2: better, faster, stronger

Motivation Polygenic scores have become a central tool in human genetics research. LDpred is a popular method for deriving polygenic scores based on summary statistics and a matrix of correlation between genetic variants. However, LDpred has limitations that may reduce its predictive performance. Results Here, we present LDpred2, a new version of LDpred that addresses these issues. We also provide two new options in LDpred2: a ‘sparse’ option...