Hierarchical and heterogeneous hydrogel system as a promising strategy for diversified interfacial tissue regeneration.

Published on Mar 10, 2021in Biomaterials Science6.183
· DOI :10.1039/D0BM01595D
Liwen Zhang1
Estimated H-index: 1
Lei Fu1
Estimated H-index: 1
+ 3 AuthorsXiaoping Yang44
Estimated H-index: 44
#1Natashya Falcone (U of T: University of Toronto)H-Index: 5
#2Tsuimy Shao (U of T: University of Toronto)H-Index: 2
Last. Heinz-Bernhard Kraatz (U of T: University of Toronto)H-Index: 45
view all 7 authors...
Peptide-based supramolecular gels can be designed to be functional “smart” materials that have applications in drug delivery, tissue engineering, and supramolecular chemistry. Although many multi-component gel systems have been designed and reported, many of these applications still rely solely on single-component gel systems which limits the functionalities of the materials. Multi-component self-assembly leads to the formation of highly ordered and complex architectures while offering the possi...
2 CitationsSource
#1Baojun Chen (Xi'an Jiaotong University)H-Index: 4
#2Yongping Liang (Xi'an Jiaotong University)H-Index: 13
Last. Zhanhai Yin (Xi'an Jiaotong University)H-Index: 7
view all 7 authors...
Abstract The fibrocartilaginous enthesis regeneration after rotator repair is still a major challenge. Although magnesium-based alloy orthopedic implant is effective to promote fibrocartilage formation at the tendon-bone interface in the anterior cruciate ligament reconstruction model, it was limited in the rotator cuff repair for its special anatomical structure. Herein, we developed a multifunctional self-healing magnesium ions-quaternized chitosan/Pluronic® F127 (Mg-QCS/PF) hydrogels to achie...
5 CitationsSource
#1Yuanyuan Zheng (JNU: Jinan University)H-Index: 4
#1Yuanyuan Zheng (JNU: Jinan University)H-Index: 1
Last. Rui Guo (JNU: Jinan University)H-Index: 17
view all 6 authors...
Prolonged inflammatory response and insufficient vascularization cause delayed and poor wound healing. In this study, we fabricated a supramolecular host-guest gelatin (HGM) hydrogel loaded with resveratrol (Res) and histatin-1 (His-1) to suppress inflammation and promote vascularization at skin burn wound sites. The HGM hydrogel showed good properties of shear-thinning and injectability, thereby allowing easy in situ injection and fast adaption to the irregular wounds. Res and His-1 were demons...
5 CitationsSource
#1Wen Zhou (NUPT: Nanjing University of Posts and Telecommunications)H-Index: 1
#2Guangzhao Yang (NUPT: Nanjing University of Posts and Telecommunications)H-Index: 1
Last. Quli Fan (NUPT: Nanjing University of Posts and Telecommunications)H-Index: 43
view all 6 authors...
Nanomaterials have been widely applied in the field of cancer imaging and therapy. However, conventional nanoparticles including micelles and liposomes may suffer the issue of dissociation in the circulation. In contrast, crosslinked nanogels the structures of which are covalently crosslinked have better physiological stability than micelles and liposomes, making them more suitable for cancer theranostics. In this review, we summarize recent advances in crosslinked nanogels for cancer imaging an...
3 CitationsSource
#1Siwei Li (Imperial College London)H-Index: 10
#2Francesca Tallia (Imperial College London)H-Index: 8
Last. Julian R. Jones (Imperial College London)H-Index: 58
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We report that 3-D printed scaffold channel size can direct bone marrow derived stem cell differentiation. Treatment of articular cartilage trauma injuries, such as microfracture surgery, have limited success because durability is limited as fibrocartilage forms. A scaffold-assisted approach, combining microfracture with biomaterials has potential if the scaffold can promote articular cartilage production and share load with cartilage. Here, we investigated human bone marrow derived stromal cell...
10 CitationsSource
#1Elham Davoodi (UW: University of Waterloo)H-Index: 7
#2Einollah Sarikhani (UCLA: University of California, Los Angeles)H-Index: 4
Last. Nureddin Ashammakhi (UCLA: University of California, Los Angeles)H-Index: 36
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This article is part of the Advanced Materials Technologies Hall of Fame article series, which recognizes the excellent contributions of leading researchers to the field of technology‐related materials science. The authors acknowledge funding from the National Institutes of Health (EB021857‐01A1, AR073135), Department of Defense: BiofabUSA Quick Start Project, the Natural Sciences and Engineering Research Council of Canada (NSERC: 50503‐10243), and the Federal Economic Development Agency for Sou...
9 CitationsSource
#1Raul A. Sun Han Chang (UIUC: University of Illinois at Urbana–Champaign)H-Index: 2
#2John Francis Shanley (UIUC: University of Illinois at Urbana–Champaign)H-Index: 1
Last. Brendan A.C. Harley (UIUC: University of Illinois at Urbana–Champaign)H-Index: 39
view all 4 authors...
1 CitationsSource
#1Hossein Jodati (METU: Middle East Technical University)H-Index: 2
#2Bengi Yilmaz (UHSA: University of Health Sciences Antigua)H-Index: 7
Last. Zafer Evis (METU: Middle East Technical University)H-Index: 20
view all 3 authors...
Abstract Tissue engineering has acquired remarkable attention as an alternative strategy to treat and restore bone defects during recent years. A scaffold is a fundamental component for tissue engineering, on which cells attach, proliferate and differentiate to form new desirable functional tissue. The composition, and structural features of scaffolds, including porosity and pore size, play a fundamental role in the success of tissue-engineered construct. This review summarizes the effect of por...
13 CitationsSource
#1Jingtong Lyu (Third Military Medical University)H-Index: 3
#2Long ChenH-Index: 12
Last. Kanglai Tang (Third Military Medical University)H-Index: 17
view all 10 authors...
The treatment to tendon-to-bone interface injury has long been challenging in sports medicine. The major obstacle lies with the complicated three-layer structure of the tissue that consists of a bone region with osteocytes, a tendon region with tenocytes and a transitional region with chondrocytes. Conventional tissue engineering approaches using simply biomaterials scaffolds, stem cells and combinations of them had limited abilities to reconstruct the gradient structure with normal biomechanica...
3 CitationsSource
#1Feichen Yang (Duke University)H-Index: 6
#2Jiacheng Zhao (Duke University)H-Index: 1
Last. Benjamin J. Wiley (Duke University)H-Index: 61
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11 CitationsSource
Cited By1
#1Santanu Panja (Glas.: University of Glasgow)H-Index: 13
#2Dave J. Adams (Glas.: University of Glasgow)H-Index: 66
Supramolecular gels are formed by the self-assembly of small molecules under the influence of various non-covalent interactions. As the interactions are individually weak and reversible, it is possible to perturb the gels easily, which in turn enables fine tuning of their properties. Synthetic supramolecular gels are kinetically trapped and usually do not show time variable changes in material properties after formation. However, such materials potentially become switchable when exposed to exter...