Hierarchical and heterogeneous hydrogel system as a promising strategy for diversified interfacial tissue regeneration.

Published on Mar 10, 2021in Biomaterials Science6.183
· DOI :10.1039/D0BM01595D
Liwen Zhang1
Estimated H-index: 1
,
Lei Fu1
Estimated H-index: 1
+ 3 AuthorsXiaoping Yang44
Estimated H-index: 44
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Abstract
References222
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Peptide-based supramolecular gels can be designed to be functional “smart” materials that have applications in drug delivery, tissue engineering, and supramolecular chemistry. Although many multi-component gel systems have been designed and reported, many of these applications still rely solely on single-component gel systems which limits the functionalities of the materials. Multi-component self-assembly leads to the formation of highly ordered and complex architectures while offering the possi...
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Prolonged inflammatory response and insufficient vascularization cause delayed and poor wound healing. In this study, we fabricated a supramolecular host-guest gelatin (HGM) hydrogel loaded with resveratrol (Res) and histatin-1 (His-1) to suppress inflammation and promote vascularization at skin burn wound sites. The HGM hydrogel showed good properties of shear-thinning and injectability, thereby allowing easy in situ injection and fast adaption to the irregular wounds. Res and His-1 were demons...
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Nanomaterials have been widely applied in the field of cancer imaging and therapy. However, conventional nanoparticles including micelles and liposomes may suffer the issue of dissociation in the circulation. In contrast, crosslinked nanogels the structures of which are covalently crosslinked have better physiological stability than micelles and liposomes, making them more suitable for cancer theranostics. In this review, we summarize recent advances in crosslinked nanogels for cancer imaging an...
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We report that 3-D printed scaffold channel size can direct bone marrow derived stem cell differentiation. Treatment of articular cartilage trauma injuries, such as microfracture surgery, have limited success because durability is limited as fibrocartilage forms. A scaffold-assisted approach, combining microfracture with biomaterials has potential if the scaffold can promote articular cartilage production and share load with cartilage. Here, we investigated human bone marrow derived stromal cell...
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This article is part of the Advanced Materials Technologies Hall of Fame article series, which recognizes the excellent contributions of leading researchers to the field of technology‐related materials science. The authors acknowledge funding from the National Institutes of Health (EB021857‐01A1, AR073135), Department of Defense: BiofabUSA Quick Start Project, the Natural Sciences and Engineering Research Council of Canada (NSERC: 50503‐10243), and the Federal Economic Development Agency for Sou...
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Supramolecular gels are formed by the self-assembly of small molecules under the influence of various non-covalent interactions. As the interactions are individually weak and reversible, it is possible to perturb the gels easily, which in turn enables fine tuning of their properties. Synthetic supramolecular gels are kinetically trapped and usually do not show time variable changes in material properties after formation. However, such materials potentially become switchable when exposed to exter...
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