Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation.

Volume: 42, Issue: 2, Pages: 101 - 132
Published: Mar 15, 2021
Abstract
Glucagon-like peptide-1 (GLP-1) is produced in gut endocrine cells and in the brain, and acts through hormonal and neural pathways to regulate islet function, satiety, and gut motility, supporting development of GLP-1 receptor (GLP-1R) agonists for the treatment of diabetes and obesity. Classic notions of GLP-1 acting as a meal-stimulated hormone from the distal gut are challenged by data supporting production of GLP-1 in the endocrine pancreas,...
Paper Details
Title
Revisiting the Complexity of GLP-1 Action from Sites of Synthesis to Receptor Activation.
Published Date
Mar 15, 2021
Volume
42
Issue
2
Pages
101 - 132
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