Solid–Liquid Phase Equilibrium and Ternary Phase Diagrams of Telmisartan-Saccharin Cocrystal in Methanol, Ethanol, and Methanol/Chloroform Mixtures at 298.15 and 313.15 K

Published on Jan 14, 2021in Journal of Chemical & Engineering Data2.369
· DOI :10.1021/ACS.JCED.0C00770
Wenju Liu2
Estimated H-index: 2
Zehua Bao2
Estimated H-index: 2
+ 1 AuthorsYajun Guo
In this work, ternary phase diagrams of telmisartan-saccharin (TEL-SAC) cocrystal in methanol, ethanol, and quasi-ternary sections of the quaternary system TEL-SAC–chloroform–methanol were determin...
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#1Guojia Yu (Huada: Beijing University of Chemical Technology)H-Index: 3
#2Xinjian Chen (Huada: Beijing University of Chemical Technology)H-Index: 3
Last. Zhongqi Ren (Huada: Beijing University of Chemical Technology)H-Index: 19
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The solubility of insoluble telmisartan (TEL) was improved by forming new cocrystal forms with several aromatic carboxylic acids. All solid forms showed three dissolution modes: TEL-HBA achieved maximum release equilibrium within 30 min and maintained stable and efficient dissolution level within 6 h. TEL-3HBA and TEL-2,5DHBA showed declining trend slowly over time up to 6 h. TEL-3,5DHBA conformed to the 'spring and parachute' model. The TEL-HBA mixture was most stable and selected for further t...