Protective effects of saponins from Panax japonicus on neurons of the colon myenteric plexus in aging rats through reduction of α‐synuclein through endoplasmic reticulum stress

Aim The enteric nervous system degenerates gradually with age, and α‐synuclein (α‐syn) is a suitable marker of enteric nervous system degeneration, which is intimately related with endoplasmic reticulum stress and unfolded protein response (UPR ER ). Saponins from Panax japonicus (SPJ) have obvious protective effects on neurons in several degenerative disease models. Here, the study was designed to investigate whether SPJ could reverse the...