Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation

Volume: 22, Issue: 12, Pages: 1436 - 1446
Published: Nov 30, 2020
Abstract
X-chromosome dosage compensation in female placental mammals is achieved by X-chromosome inactivation (XCI). Human pre-implantation embryos are an exception, in which dosage compensation occurs by X-chromosome dampening (XCD). Here, we examined whether XCD extends to human prenatal germ cells given their similarities to naive pluripotent cells. We found that female human primordial germ cells (hPGCs) display reduced X-linked gene expression...
Paper Details
Title
Female human primordial germ cells display X-chromosome dosage compensation despite the absence of X-inactivation
Published Date
Nov 30, 2020
Volume
22
Issue
12
Pages
1436 - 1446
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