Recent insights into the regulatory networks of NLRP3 inflammasome activation
Abstract
The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a fascinating cellular machinery endowed with the capacity for rapid proteolytic processing of the pro-inflammatory cytokine IL-1β and the cell death effector gasdermin D (GSDMD). Although its activity is essential to fight infection and support tissue homeostasis, the inflammasome complex, which consists of the danger sensor NLRP3, the adaptor apoptosis-associated...
Paper Details
Title
Recent insights into the regulatory networks of NLRP3 inflammasome activation
Published Date
Dec 1, 2020
Journal
Volume
133
Issue
23
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