Adding brain volume measures into response criteria in multiple sclerosis: the Río-4 score

Brain volume changes (BVC) on therapy in MS are being considered as predictor for treatment response at an individual level. We ought to assess whether adding BVC as a factor to monitor interferon-beta response improves the predictive ability of the (no) evidence of disease activity (EDA-3) and Rio score (RS-3) criteria for confirmed disability progression in a historical cohort. One hundred one patients from an observational cohort treated with...