Isogeometric analysis of subcutaneous injection of monoclonal antibodies

Subcutaneous injection for self-administration of biotherapeutics, such as monoclonal antibodies, has emerged as a fast-growing field in the pharmaceutical industry. Effective drug delivery in the subcutaneous tissue critically depends on the coupled mechanical and transport processes occurring in the tissue during and after the injection. The details of these processes, however, remain poorly understood; and this explains the growing interest...