Biology

Toxicology

Botany

Mode of action

Broad spectrum

Biochemistry

Pharmacology

Antifungal

Antifungal drug

Polyene

Amphotericin B

Drug

Fungicide

Chemistry

Antifungal drugs

Drug resistance

Combinatorial chemistry

Microbiology

Journal of Fungi

Although polyenes were the first broad spectrum antifungal drugs on the market, after 70 years they are still the gold standard to treat a variety of fungal infections. Polyenes such as amphotericin B have a controversial image. They are the antifungal drug class with the broadest spectrum, resistance development is still relatively rare and fungicidal properties are extensive. Yet, they come with a significant host toxicity that limits their use. Relatively recently, the mode of action of polyenes has been revised, new mechanisms of drug resistance were discovered and emergent polyene resistant species such as

Amphotericin B and Other Polyenes—Discovery, Clinical Use, Mode of Action and Drug Resistance