PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation
Abstract
Protein kinase R-like endoplasmic reticulum kinase (PERK) is one of the endoplasmic reticulum (ER) stress sensors. PERK loss-of-function mutations are known to cause Wolcott–Rallison syndrome. This disease is characterized by early-onset diabetes mellitus, skeletal dysplasia, and cardiac valve malformation. To understand the role of PERK in valve formation in vivo, we used an endothelial-specific PERK conditional knockout mice as well as in...
Paper Details
Title
PERK participates in cardiac valve development via fatty acid oxidation and endocardial-mesenchymal transformation
Published Date
Nov 18, 2020
Journal
Volume
10
Issue
1
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