Physics

Pathology

Receptor

Virus

Disease

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Monoclonal antibody

Biology

Förster resonance energy transfer

Biophysics

Viral replication

Antibody

Virology

Allosteric regulation

Immunology

Conformational change

Coronavirus

Immunogen

Quantum mechanics

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Biochemistry

Viral entry

Medicine

Fluorescence

Cell Host & Microbe

The SARS-CoV-2 spike protein has been observed to adopt different structural states. Lu et al. directly visualize the conformational dynamics of spike protein on the surface of virus particles and describe how the conformational landscape changes upon activation by the host receptor or antagonism by antibodies.

Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles