Combined cryosurgery and cold-responsive drug-loaded nanoparticles to enhance deep-lying tumor therapy: A mathematical model

Minimally-invasive cryosurgery is incapable of killing the tumor at the outer periphery of iceball, resulting in the inefficiency of tumor treatment. In this paper, we develop a new combined treatment of chemotherapy and cryotherapy (chemo-cryo) by injecting cold-responsive drug-loaded nanoparticles around the tumor before cryosurgery to enhance the treatment of deep-lying tumor. A macroscopic mathematical model is established for the first...