Rhodium(III)-Catalyzed C–H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes

Volume: 22, Issue: 23, Pages: 9163 - 9168
Published: Nov 16, 2020
Abstract
An efficient Rh(III)-catalyzed C–H alkenylation/directing group migration cascade between indoles and alkynes for the assembly of tetrasubstituted alkenes is reported. The carbamoyl directing group migrates to the carbon of the alkene moiety of the products through rare Rh-catalyzed C–N bond cleavage after the C–H alkenylation step and thus acts as an internal amidation reagent. This protocol shows broad substrate scope, excellent...
Paper Details
Title
Rhodium(III)-Catalyzed C–H Alkenylation/Directing Group Migration for the Regio- and Stereoselective Synthesis of Tetrasubstituted Alkenes
Published Date
Nov 16, 2020
Volume
22
Issue
23
Pages
9163 - 9168
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