Original paper
Cellular Fucosylation Inhibitors Based on Fluorinated Fucose‐1‐phosphates**
Abstract
Fucosylation of glycans impacts a myriad of physiological and pathological processes. Inhibition of fucose expression emerges as a potential therapeutic avenue for example in cancer, inflammation, and infection. In this study, we found that protected 2‐fluorofucose 1‐phosphate efficiently inhibits cellular fucosylation with a four to seven times higher potency than known inhibitor 2FF, independently of the anomeric stereochemistry. Nucleotide...
Paper Details
Title
Cellular Fucosylation Inhibitors Based on Fluorinated Fucose‐1‐phosphates**
Published Date
Feb 2, 2021
Volume
27
Issue
12
Pages
4022 - 4027
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Notes
History