t-cell lymphomas

diffuse large

cell lymphoma

epstein-barr virus

large cell lymphoma

lymphoproliferative disorders

hodgkin disease

non-hodgkin lymphoma

lymphomas

anaplastic large cell

Journal of the National Comprehensive Cancer Network

Hepatosplenic T-cell lymphoma (HSTCL) is a rare subtype of T-cell lymphoma associated with an aggressive clinical course and a worse prognosis. HSTCL develops in the setting of chronic immune suppression or immune dysregulation in up to 20% of cases and is most often characterized by spleen, liver, and bone marrow involvement. Diagnosis and management of HSTCL pose significant challenges given the rarity of the disease along with the absence of lymphadenopathy and poor outcome with conventional chemotherapy regimens. These Guidelines Insights focus on the diagnosis and treatment of HSTCL as outlined in the NCCN Guidelines for T-Cell Lymphomas.

NCCN Guidelines Insights: T-Cell Lymphomas, Version 1.2021