Journal of The National Comprehensive Cancer Network
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9.32
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2481
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#1Aida Bujosa (Autonomous University of Barcelona)
#2Consolación Molto (Autonomous University of Barcelona)H-Index: 4
Last. Ariadna Tibau (Autonomous University of Barcelona)H-Index: 12
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Background null Most anticancer drugs are approved by regulatory agencies based on surrogate measures. This article explores the variables associated with overall survival (OS), quality of life (QoL), and substantial clinical benefit among anticancer drugs at the time of approval and in the postmarketing period. null Methods null Anticancer drugs approved by the FDA between January 2006 and December 2015 and with postmarketing follow-up until April 2019 were identified. We evaluated trial-level ...
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#1Anusha Ponduri (Albert Einstein College of Medicine)H-Index: 1
#2David Liao (Albert Einstein College of Medicine)H-Index: 3
Last. Richard V. Smith (Montefiore Medical Center)H-Index: 30
view all 11 authors...
BACKGROUND Nonadherence to NCCN Guidelines during time from surgery to postoperative radiotherapy (S-PORT) can alter survival outcomes in head and neck squamous cell carcinomna (HNSCC). There is a need to validate this impact in an underserved urban population and to understand risk factors and reasons for delay. We sought to investigate the impact of delayed PORT with outcomes of overall survival (OS) in HNSCC, to analyze predictive factors of delayed PORT, and to identify reasons for delay. ME...
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Recurrent GLI1 gene fusions have been recently described in a subset of soft tissue tumors showing a distinct monotonous epithelioid morphology with a rich capillary network and frequent S100 protein expression. Three different fusion partners-ACTB, MALAT1, and PTCH1-have been reported with the PTCH1-GLI1 fusion from 2 patients only, both with head and neck tumors. Herein, we report for the first time a PTCH1-GLI1 fusion in a primary ovarian tumor from a female patient aged 54 years who presente...
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#1T. V. Johnson (National Comprehensive Cancer Network)H-Index: 2
Last. Robert W. Carlson (National Comprehensive Cancer Network)H-Index: 66
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The cost of delivering high-quality healthcare in America now consumes 17.7% of the nation's gross domestic product according to Centers for Medicare & Medicaid Services National Health Expenditure Data. With costs threatening to disrupt accessible and equitable care for patients, policymakers are reassessing all matters and functions of the healthcare system to excise waste, redundancies, and costly services. To explore this subjects' impact on oncology, NCCN hosted the NCCN Policy Summit: Inno...
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#1Efrat Dotan (Fox Chase Cancer Center)H-Index: 20
#2Louise C. Walter (UCSF: University of California, San Francisco)H-Index: 51
Last. Joleen M. Hubbard (Mayo Clinic)H-Index: 21
view all 32 authors...
The NCCN Guidelines for Older Adult Oncology address specific issues related to the management of cancer in older adults, including screening and comprehensive geriatric assessment (CGA), assessing the risks and benefits of treatment, preventing or decreasing complications from therapy, and managing patients deemed to be at high risk for treatment-related toxicity. CGA is a multidisciplinary, in-depth evaluation that assesses the objective health of the older adult while evaluating multiple doma...
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#1Yu Tian (DKFZ: German Cancer Research Center)H-Index: 4
#2Elham Kharazmi (DKFZ: German Cancer Research Center)H-Index: 17
Last. Mahdi Fallah (DKFZ: German Cancer Research Center)H-Index: 21
view all 7 authors...
BACKGROUND The aim of this study was to explore the risk of invasive colorectal cancer (CRC) in relatives of patients with colorectal carcinoma in situ (CCIS), which is lacking in the literature. PATIENTS AND METHODS We collected data from Swedish family-cancer datasets and calculated standardized incidence ratio (SIR) and cumulative risk of CRC in family histories of CCIS in first- and second-degree relatives. Family history was defined as a dynamic (time-dependent) variable allowing for change...
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#1Camilla ZimmermannH-Index: 61
#2Ashley PopeH-Index: 10
Last. Srikala S. Sridhar (Princess Margaret Cancer Centre)H-Index: 31
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BACKGROUND Routine early palliative care (EPC) improves quality of life (QoL) for patients with advanced cancer, but it may not be necessary for all patients. We assessed the feasibility of Symptom screening with Targeted Early Palliative care (STEP) in a phase II trial. METHODS Patients with advanced cancer were recruited from medical oncology clinics. Symptoms were screened at each visit using the Edmonton Symptom Assessment System-revised (ESAS-r); moderate to severe scores (screen-positive) ...
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#1Chetna MalhotraH-Index: 17
#2Rahul Malhotra (NUS: National University of Singapore)H-Index: 29
Last. Eric A. FinkelsteinH-Index: 66
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Background null Reducing suffering at the end of life is important. Doing so requires a comprehensive understanding of the course of suffering for patients with cancer during their last year of life. This study describes trajectories of psychological, spiritual, physical, and functional suffering in the last year of life among patients with a solid metastatic cancer. null Patients and methods null We conducted a prospective cohort study of 600 patients with a solid metastatic cancer between July...
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