Review paper
Ying and Yang of Stat3 in pathogenesis of aortic dissection
Abstract
Aortic dissection (AD) is a medical emergency, in which acute destruction of aortic wall occurs with unknown etiology. Recent studies have uncovered the critical role of inteleukin-6 (IL-6) and inflammatory cells including macrophages in the disease mechanism of AD. IL-6 activates janus kinase and signal transducer and activator of transcription 3 (STAT3) to alter the gene expression program in many cell types, thus regulating various aspects of...
Paper Details
Title
Ying and Yang of Stat3 in pathogenesis of aortic dissection
Published Date
May 1, 2021
Journal
Volume
77
Issue
5
Pages
471 - 474
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