Solubility determination and thermodynamic modelling of Progesterone in twelve pure solvents and three binary solvents at 278.15 to 323.15 K

The solubility of Progesterone at T = 278.15–323.15 K was measured by static equilibrium method combined with HPLC in twelve solvents (methanol, ethanol, isopropanol, n-propanol, n-butanol, acetone, tetrahydrofuran, 1,4-dioxane, n-heptane, ethyl acetate, acetonitrile, and toluene) and three binary solvents (tetrahydrofuran + n-heptane, 1,4-dioxane + n-heptane, and toluene + n-heptane). The results showed that progesterone has the highest...