Original paper
Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis
Volume: 16, Issue: 16, Pages: 3163 - 3173
Published: Jan 1, 2020
Abstract
Background: Acute gouty arthritis is a common inflammatory arthropathy resulting from urate deposition in joints during persistent hyperuricemia. Nevertheless, effective therapeutic strategies are still unavailable. Here, we propose the crucial role of bromodomain-containing protein 4 (BRD4) in acute gouty arthritis. Methods: Therapeutic effect of BRD4 specific inhibitor JQ-1 on acute gouty arthritis was evaluated in vivo and in vitro....
Paper Details
Title
Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis
Published Date
Jan 1, 2020
Volume
16
Issue
16
Pages
3163 - 3173
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Notes
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