From Multi-Omics Approaches to Precision Medicine in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disorder, characterized by upper and lower motor neuron degeneration for which there is no truly effective treatment. The lack of successful treatments can be explained in part by the complex and heterogeneous nature of ALS, with patients displaying widely different patterns of disease manifestation and progression, and molecular analyses suggesting heterogeneity of...