Non-cytokine activation immunoprofiling to differentiate treatment status in latent tuberculosis infection

Rationale: Assessment of reactivation risk for latent tuberculosis infection (LTBI) remains challenging. We previously reported a non-cytokine immunoprofiling strategy based on a flow cytometric (FC) detection of co-expression of CD25 (IL-2α receptor) and CD134 (OX40 TNFa receptor superfamily) that differentiates unexposed subjects, treated LTBI, and untreated LTBI subjects. We aim to test if an immunoprofiling based on co-expression of...