Effect of body mass index on response to neo-adjuvant therapy in HER2-positive breast cancer: an exploratory analysis of the NeoALTTO trial.

Published on Oct 27, 2020in Breast Cancer Research4.988
· DOI :10.1186/S13058-020-01356-W
Serena Di Cosimo28
Estimated H-index: 28
Luca Porcu16
Estimated H-index: 16
+ 10 AuthorsEvandro de Azambuja48
Estimated H-index: 48
(ULB: Université libre de Bruxelles)
#1Monica M. Reinholz (Mayo Clinic)H-Index: 21
#2Beiyun Chen (Mayo Clinic)H-Index: 15
Last. Edith A. Perez (Mayo Clinic)H-Index: 83
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Background: Preclinical evidence indicates that increased insulin-like growth factor receptor-1 (IGF1R) signaling interferes with the action of trastuzumab suggesting a possible mechanism of trastuzumab resistance. Thus, we evaluated IGF1R prevalence, relationship with demographic data, and association with disease-free survival (DFS) of patients randomized to chemotherapy alone (Arm A) or chemotherapy with sequential (Arm B) or concurrent trastuzumab (Arm C) in the prospective phase III HER2 + ...
3 CitationsSource
#1Martina McDermott (DCU: Dublin City University)H-Index: 8
#2Alexandra Canonici (DCU: Dublin City University)H-Index: 8
Last. Norma O'Donovan (DCU: Dublin City University)H-Index: 31
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Abstract Although HER2 targeted therapies have improved prognosis for HER2 positive breast cancer, HER2 positive cancers which co-express ER have poorer response rates to standard HER2 targeted therapies, combined with chemotherapy, than HER2 positive/ER negative breast cancer. Administration of hormone therapy concurrently with chemotherapy and HER2 targeted therapy is generally not recommended. Using publically available gene expression datasets we found that high expression of IGF1R is associ...
8 CitationsSource
PurposeTo summarize the evidence of an association between obesity and breast cancer prognosis.MethodsWe reviewed the literature regarding overweight and obesity and breast cancer survival outcomes, overall and with regard to breast cancer subtypes, breast cancer therapies, biologic mechanisms, and possible interventions. We summarize our findings and provide clinical management recommendations.ResultsObesity is associated with a 35% to 40% increased risk of breast cancer recurrence and death an...
105 CitationsSource
In this article, we focus on the subtype of estrogen receptor (ER)-positive, human epidermal growth factor 2 (HER2)-positive breast cancer (BC). Preclinical and clinical data indicate a complex molecular bidirectional crosstalk between the ER and HER2 pathways. This crosstalk probably constitutes one of the key mechanisms of drug resistance in this subclass of BC. Delaying or even reversing drug resistance seems possible by targeting pathways implicated in this crosstalk. High-risk patients curr...
18 CitationsSource
#1Arpine GevorgyanH-Index: 8
#2Giacomo BregniH-Index: 6
Last. Serena Di CosimoH-Index: 28
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Abstract Obesity is a known risk factor for breast cancer and has been linked to increased risk of recurrence and death in breast cancer patients. Little is known about the predictive value of obesity. As endocrine therapy is widely used for breast cancer treatment worldwide, we aimed at correlating baseline body mass index (BMI) with clinical benefit derived from fulvestrant in postmenopausal women with advanced breast cancer. We analyzed consecutive patients treated with fulvestrant in our cen...
9 CitationsSource
#1S. Schmidt (UW: University of Waterloo)H-Index: 1
#2Jennifer M. Monk (U of G: University of Guelph)H-Index: 21
Last. Marina Mourtzakis (UW: University of Waterloo)H-Index: 27
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Obesity is an established risk factor for postmenopausal breast cancer. The mechanisms through which obesity influences the development and progression of breast cancer are not fully elucidated; however, several factors such as increased oestrogen, concentrations of various members of the insulin family and inflammation that are associated with adiposity are purported to be important factors in this relationship. Emerging research has also begun to focus on the role of adipokines, (i.e. adipocyt...
44 CitationsSource
#1Varsha Brahmkhatri (IISc: Indian Institute of Science)H-Index: 13
#2Chinmayi Prasanna (IISc: Indian Institute of Science)H-Index: 3
Last. Hanudatta S. Atreya (IISc: Indian Institute of Science)H-Index: 24
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Insulin-like growth factors (IGFs) are essential for growth and survival that suppress apoptosis and promote cell cycle progression, angiogenesis, and metastatic activities in various cancers. The IGFs actions are mediated through the IGF-1 receptor that is involved in cell transformation induced by tumour. These effects depend on the bioavailability of IGFs, which is regulated by IGF binding proteins (IGFBPs). We describe here the role of the IGF system in cancer, proposing new strategies targe...
130 CitationsSource
Obesity is associated with an increased risk of breast cancer (BC) and poorer outcome. We assessed the impact of body mass index (BMI) on pathological complete response (pCR), disease-free (DFS), and overall survival (OS), according to BC subtypes in patients with primary BC treated with neoadjuvant chemotherapy. 8,872 patients with primary BC from eight neoadjuvant trials were categorized according to BMI: underweight (<18.5 kg/m2), normal weight (18.5 to <25 kg/m2), overweight (25 to <30 kg/m2...
55 CitationsSource
#1Travis B. Salisbury (Marshall University)H-Index: 7
#2Justin K. Tomblin (Marshall University)H-Index: 6
The insulin-like growth factor 1 receptor (IGF1R) and the insulin receptor (IR) are receptor tyrosine kinases (RTKs) that are expressed in cancer cells. The results of different studies indicate that tumor proliferation and survival is dependent on the IGF1R and IR, and that their inhibition leads to reductions in proliferation and increases in cell death. Molecular targeting therapies that have been used in solid tumors include: anti-IGF1R antibodies, anti-IGF1/IGF2 antibodies and small molecul...
23 CitationsSource
#1D. S. M. Chan (Imperial College London)H-Index: 11
#2A. R. Vieira (Imperial College London)H-Index: 18
Last. Teresa Norat (Imperial College London)H-Index: 84
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Background: Positive association between obesity and survival after breast cancer was demonstrated in previous meta-analyses of published data, but only the results for the comparison of obese versus non-obese was summarised. Methods: We systematically searched in MEDLINE and EMBASE for follow-up studies of breast cancer survivors with body mass index (BMI) before and after diagnosis, and total and cause-specific mortality until June 2013, as part of the World Cancer Research Fund Continuous Upd...
494 CitationsSource
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