Analysis of the structures and functions of N-glycans of MET

EGFR-TKI is a most important drug in the treatment of lung cancer and it is important that development of resistance to the drug be overcome. MET amplification has been associated with the drug resistance, but although many agents targeting MET have been studied, they have not yet been clinically applied. To develop new agents targeting MET, it is necessary to clarify its physical property. Considerable evidence has shown that the MET glycans...