Internal medicine

Pathology

Observational study

Intensive care medicine

Prospective cohort study

Fibrinolysis

Longitudinal study

Hemostasis

Thrombin

Coagulopathy

Thrombin generation

Medicine

Platelet

Thrombosis Research

Coronavirus disease 2019 (COVID-19) is associated with marked albeit variable hemostasis disturbances and high thrombotic risk [1]. Measurement of plasma D-dimers levels has been put forward as a prognostic marker [2]. However, more comprehensive functional tests, such as thrombin generation and fibrinolysis assay, could also be of clinical relevance to estimate risks of poor outcome and to guide individual anticoagulation. To the best of our knowledge, few studies only describe the longitudinal follow-up of hemostasis parameters - a worrying gap in the close assessment of the course of the hemostasis disturbances during the acute phase of the disease.

Prothrombotic disturbances of hemostasis of patients with severe COVID-19: A prospective longitudinal observational study