Study of common quantification methods of amide proton transfer magnetic resonance imaging for ischemic stroke detection

Purpose To assess the correlation and differences between common amide proton transfer (APT) quantification methods in the diagnosis of ischemic stroke. Methods Five APT quantification methods, including asymmetry analysis and its variants as well as two Lorentzian model‐based methods, were applied to data acquired from six rats that underwent middle cerebral artery occlusion scanned at 9.4T. Diffusion and perfusion‐weighted images, and water...