Original paper
SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration
Abstract
Leber congenital amaurosis type nine is an autosomal recessive retinopathy caused by mutations of the NAD+ synthesis enzyme NMNAT1. Despite the ubiquitous expression of NMNAT1, patients do not manifest pathologies other than retinal degeneration. Here we demonstrate that widespread NMNAT1 depletion in adult mice mirrors the human pathology, with selective loss of photoreceptors highlighting the exquisite vulnerability of these cells to NMNAT1...
Paper Details
Title
SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration
Published Date
Oct 27, 2020
Journal
Volume
9
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Notes
History