Research on scheduling problems is an evergreen challenge for industrial engineers. The growth of digital technologies opens the possibility to collect and analyze great amount of field data in real-time, representing a precious opportunity for an improved scheduling activity. Thus, scheduling under uncertain scenarios may benefit from the possibility to grasp the current operating conditions of the industrial equipment in real-time and take them into account when elaborating the best production schedules. To this end, the article proposes a proof-of-concept of a simheuristics framework for robust scheduling applied to a Flow Shop Scheduling Problem. The framework is composed of genetic algorithms for schedule optimization and discrete event simulation and is synchronized with the field through a Digital Twin (DT) that employs an Equipment Prognostics and Health Management (EPHM) module. The contribution of the EPHM module inside the DT-based framework is the real time computation of the failure probability of the equipment, with data-driven statistical models that take sensor data from the field as input. The viability of the framework is demonstrated in a flow shop application in a laboratory environment.