Improved Synthesis and Preclinical Evaluation of [18F]FNP-59: a Radiotracer for Imaging Cholesterol Trafficking

976 null Objectives: null null We previously reported the synthesis of FNP-59, a novel fluorinated analogue of NP-59 and cholesterol[1]. Cholesterol is normally trafficked to adrenal cortical tissue where it is esterified by ACAT1 for storage and used in the synthesis of hormones. In atherosclerotic disease foam cells also express ACAT1 for esterifying cholesterol to store and prepare it for transport and elimination. A higher yielding concise...