DNA-Encoded Chemistry: Drug Discovery from a Few Good Reactions

Volume: 121, Issue: 12, Pages: 7155 - 7177
Published: Oct 12, 2020
Abstract
Click chemistry, proposed nearly 20 years ago, promised access to novel chemical space by empowering combinatorial library synthesis with a "few good reactions". These click reactions fulfilled key criteria (broad scope, quantitative yield, abundant starting material, mild reaction conditions, and high chemoselectivity), keeping the focus on molecules that would be easy to make, yet structurally diverse. This philosophy bears a striking...
Paper Details
Title
DNA-Encoded Chemistry: Drug Discovery from a Few Good Reactions
Published Date
Oct 12, 2020
Volume
121
Issue
12
Pages
7155 - 7177
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