Internal medicine

Inoculation

Virus

Disease

Cattle Diseases

Coronavirus disease 2019 (COVID-19)

Infectious disease (medical specialty)

Biology

Outbreak

Viral replication

Antibody

Virology

Immunology

Betacoronavirus

Coronavirus

2019-20 coronavirus outbreak

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Titer

Medicine

Emerging infectious diseases

We inoculated 6 cattle with severe acute respiratory syndrome coronavirus 2 and kept them together with 3 uninoculated cattle. We observed viral replication and specific seroreactivity in 2 inoculated animals, despite high levels of preexisting antibody titers against a bovine betacoronavirus. The in-contact animals did not become infected.

Experimental Infection of Cattle with SARS-CoV-2