New 30-substituted derivatives of pentacyclic triterpenes: preparation, biological activity, and molecular docking study

A series of 30-substituted derivatives of 3,28-O,O′-diacetylbetulin 4-19 were prepared and assessed for anticancer activities in vitro against five human cancer cell lines (SNB-19, C-32, SKOV-3, MCF-7, and T47D). The triterpene 14, containing the butyryloxycarbonyl group at the C-30 position, showed the highest cytotoxicity, with IC50 values within the range of 1.24 to 6.03 µM towards applied cancer cells. The ADME study of the betulinines 4-19...