A novel two-component, expandable bioadhesive for exposed defect coverage: Applicability to prenatal procedures

We sought to test select properties of a novel, expandable bioadhesive composite that allows for enhanced adhesion control in liquid environments.Rabbit fetuses (n = 23) underwent surgical creation of spina bifida on gestational day 22-25 (term 32-33 days). Defects were immediately covered with a two-component tough adhesive consisting of a hydrogel made of a double network of ionically crosslinked alginate and covalently crosslinked...