Epitranscriptomic regulation by m⁶A RNA methylation in brain development and diseases

Cellular RNAs are pervasively tagged with diverse chemical moieties, collectively called epitranscriptomic modifications. The methylation of adenosine at N 6 position generates N 6 -methyladenosine (m 6 A), which is the most abundant and reversible epitranscriptomic modification in mammals. The m 6 A signaling is mediated by a dedicated set of proteins comprised of writers, erasers, and readers. Contrary to the activation–repression binary view...