Matrix stiffness‐mediated effects on macrophages polarization and their LOXL2 expression

Previously, we reported that the secreted lysyl oxidase like 2 (LOXL2) from hepatocellular carcinoma (HCC) cells under higher stiffness stimulation contributed to the formation of lung premetastatic niche. To further clarify whether matrix stiffness also alters LOXL2 expression in other cells within tumor microenvironment, we developed a gel‐based culture system combined with a model of macrophage polarization to evaluate the effects of matrix...