Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture

Volume: 11, Issue: 1, Pages: 1 - 11
Published: Sep 23, 2020
Abstract
Genetic association studies have identified 44 common genome-wide significant risk loci for late-onset Alzheimer’s disease (LOAD). However, LOAD genetic architecture and prediction are unclear. Here we estimate the optimal P-threshold (Poptimal) of a genetic risk score (GRS) for prediction of LOAD in three independent datasets comprising 676 cases and 35,675 family history proxy cases. We show that the discriminative ability of GRS in LOAD...
Paper Details
Title
Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
Published Date
Sep 23, 2020
Volume
11
Issue
1
Pages
1 - 11
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