Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation
Abstract
Specific E3 ligases target tumor suppressors for degradation. Inhibition of such E3 ligases may be an important approach to cancer treatment. RNF146 is a RING domain and PARylation-dependent E3 ligase that functions as an activator of the β-catenin/Wnt and YAP/Hippo pathways by targeting the degradation of several tumor suppressors. Tankyrases 1 and 2 (TNKS1/2) are the only known poly-ADP-ribosyltransferases that require RNF146 to degrade their...
Paper Details
Title
Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation
Published Date
Dec 1, 2020
Volume
19
Issue
12
Pages
2015 - 2030
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