wound repair

dermal fibroblasts

wounds

Advanced Drug Delivery Reviews

Fibronectin structure and composition regulate contextual cell signaling. Recent advances have been made in understanding fibronectin and its role in tissue organization and repair. This review outlines fibronectin splice variants and their functions, evaluates potential therapeutic strategies targeting or utilizing fibronectin, and concludes by discussing potential future directions to modulate fibronectin function in development and wound healing. • Recent advances studying the role of fibronectin in development indicate potential applications for repairing fetal defects. • Spatio-temporal regulation of fibronectin isoforms and peptides may mediate therapeutic cell signaling during wound healing.. • Fibronectin and growth factors recapitulating developmental signaling may improve wound repair and induce regeneration.

Fibronectin in development and wound healing