The effects of intravenous and local tranexamic acid on bone healing: An experimental study in the rat tibia fracture model

Background Tranexamic acid (TXA) is an antifibrinolytic agent. It has long been used to reduce the need for perioperative blood loss in various surgeries. Few studies have investigated the effects of local and intravenous administration of TXA on fracture healing. Thus, we aimed to evaluate if TXA influences hematoma volume and fracture healing in the rat tibia fracture model. Materials and methods A tibia fracture with intramedullary Kirschner...