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Original paper

Next-Generation Total Synthesis of Vancomycin

Volume: 142, Issue: 37, Pages: 16039 - 16050
Published: Sep 4, 2020
Abstract
A next-generation total synthesis of vancomycin aglycon is detailed that was achieved in 17 steps (longest linear sequence, LLS) from the constituent amino acid subunits with kinetically controlled diastereoselective introduction of all three elements of atropisomerism. In addition to new syntheses of three of the seven amino acid subunits, highlights of the approach include a ligand-controlled atroposelective one-pot Miyaura borylation–Suzuki...
Paper Details
Title
Next-Generation Total Synthesis of Vancomycin
Published Date
Sep 4, 2020
Volume
142
Issue
37
Pages
16039 - 16050
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