Incorporation of Hydroxyapatite/Doxorubicin into the Chitosan/Polyvinyl Alcohol/Polyurethane Nanofibers for Controlled Release of Doxurubicin and Its Anticancer Property

In the present study, the doxorubicin-hydroxyapatite (DOX-HAp) has been loaded into the chitosan/PVA/PU single layer and core-shell nanofibers. The potential of synthesized nanofibers was evaluated for controlled release of DOX and bone cancer treatment in vitro. The synthesized DOX-HAp nanohybrid was characterized using XRD, SEM, and UV-Vis analysis. The morphology of synthesized nanofibers was examined by SEM and TEM analysis. For single layer...