Original paper
<p>PARP Inhibitors in Metastatic Prostate Cancer: Evidence to Date</p>
Abstract
Poly (ADP-ribose) polymerase inhibitors (PARPi) are a unique class of antineoplastic agents that function by inducing synthetic lethality. Synthetic lethality occurs when PARPi and either another agent or an underlying genetic alteration together lead to overwhelming DNA damage and ultimately cell death. PARPi first showed promise as a cancer therapy in patients with BRCA1/2 mutations and have become part of standard treatment for breast and...
Paper Details
Title
<p>PARP Inhibitors in Metastatic Prostate Cancer: Evidence to Date</p>
Published Date
Sep 1, 2020
Volume
Volume 12
Pages
8105 - 8114
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Notes
History